Differentially Methylated Loci vs Differentially Methylated Regions

Cited from the paper "BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions"

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However, various authors have noted that methylation levels are strongly correlated across the genome [24, 25]. Furthermore, functionally relevant findings are generally associated with genomic regions rather than single CpGs, either CpG islands [26], CpG island shores [27], genomic blocks [1], or generic 2 kb regions [3].
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