p300 and CREB-binding protein (CBP)

Excerpts from "Enhancer function: new insights into the regulation of tissue-specific gene expression"

"CBP (CREB-binding protein) and p300 are highly similar proteins that have histone acetyltransferase activity and contain a variety of functional domains involved in interactions with other transcription factors or histone modifications²⁹. These two proteins interact with the sequence-specific binding transcription factor CREB (Cyclic-AMP Response Element Binding) and have been previously shown to be involved in several cell signaling pathways by activating the transcription of a variety of genes."

"Cell-type specific occupancy of enhancers by CBP/p300 regulates distinct transcriptional programs in many cell types¹² and, therefore, these proteins may be a general component of a large class of enhancer elements."