Excerpts from "Promoter directionality is controlled by U1 snRNP and polyadenylation signals"
"Active promoters were defined as promoters with GRO-seq signal detected within the first 1 kb downstream of the sense strand. A promoter was considered divergent if it contained GRO-seq signal in the first 1 kb downstream of the sense strand and within the first 2 kb of the upstream antisense strand. A minimum number of two reads within the defined window (downstream 1 kb or upstream 2 kb) was used as a cutoff for background signals."
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