High-Throughput (HT) SELEX combines SELEX (Systematic Evolution of Ligands by EXponential Enrichment)

Cited from SELEX experiments: new prospects, applications and data analysis in inferring regulatory pathways

"Systematic Evolution of Ligands by EXponential enrichment (SELEX) is an experimental procedure that allows extraction, from an initially random pool of oligonucleotides, of the oligomers with a desired binding affinity for a given molecular target."

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Cited from Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery

Aptamers: short (20–100 nucleotides), synthetic, single-stranded (ribo)-nucleic molecules.

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Cited from Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities

We describe here a high-throughput method for analyzing transcription factor binding specificity that is based on systematic evolution of ligands by exponential enrichment (SELEX) and massively parallel sequencing.