"Replication starts from a set of initiation loci, called replication
origins, where two replication forks are assembled and begin replicating
DNA while proceeding in opposite directions, away from the loci; fork
progression continues until two converging forks 'collide' at a terminus
of replication."
"The DNA replication program in a cell is defined as the temporal
sequence of locus replication events during the S phase. The program
depends on the locations of the replication origins, their activation
times and the speed at which replication forks move along the DNA double
helix."
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