Saturday 3 September 2016

Mitosis-specific Histone Modifications

Cited from the review "Chromosome  Condensation and Cohesion"

"H3-S10 phosphorylation is mediated by the Aurora B kinase.It initiates at centromeres in late G2 and extends to the whole chromosome by early mitosis."

"Phosphorylation of H3-S10 dissociates chromatin-bound proteins such as heterochromatin protein 1 (HP1) and splicing factors SRp20 and ASF/SF2 during mitosis, suggesting that this phosphorylation event might contribute to chromosome condensation by removing chromatin-bound proteins ."

"In addition to histone H3, the linker histone H1 is also
heavily phosphorylated during mitosis, which has been
implicated in chromosome condensation."



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