Cited from the Paper Distinct factors control histone variant H3.3 localization at specific genomic regions
Mammalian cells express three major types of non-centromeric histone H3 variants, H3.1, H3.2, and H3.3. Although histone H3.3 differs from H3.2 and H3.1 at only 4 or 5 amino acids, H3.3 is specifically enriched at transcriptionally active genes and regulatory elements in non-pluripotent cells.
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