Cohesin complexes co-localize with CCCTC binding factor (CTCF) at most of their binding sites in mammalian genomes. CTCF is a sequence-specific DNA-binding protein involved in the formation of chromatin loops, while cohesin associates with chromatin independently of the DNA sequence.
Thursday 15 June 2017
Cohesin and CTCF
Cited from News & Review Genome Organization: Cohesin on the Move
Cohesin complexes co-localize with CCCTC binding factor (CTCF) at most of their binding sites in mammalian genomes. CTCF is a sequence-specific DNA-binding protein involved in the formation of chromatin loops, while cohesin associates with chromatin independently of the DNA sequence.
Cohesin complexes co-localize with CCCTC binding factor (CTCF) at most of their binding sites in mammalian genomes. CTCF is a sequence-specific DNA-binding protein involved in the formation of chromatin loops, while cohesin associates with chromatin independently of the DNA sequence.
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