Cited from the paper Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells
Genome-wide single-base–resolution mammalian methylome studies have revealed that most of the cytosine in CpG dinucleotides is methylated, presumably during blastocyst to early postimplantation stages by DNA methyltransferase 3A (DNMT3A)– and/or DNMT3B-mediated de novo methylation.
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